Endocrine Abstracts

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Emerging evidence indicates that the hypothalamus is a key regulator of the adaptation of the central nervous system (CNS) to the changing environment in support of survival, with subsets of hypothalamic neurons acting as upstream regulators of brain regions classically considered as master determinants of CNS function, such as the cortex and hippocampus. The regulatory role of the hypothalamus in cortical and hippocampal functions is mediated via classical neuronal pathways a...

Significant advancements have been made in the last century regarding the neuronal control of feeding behavior and energy expenditure. The effects and mechanism of action of various peripheral metabolic signals on the brain have become clearer. Molecular and genetic tools for visualizing and manipulating individual components of brain homeostatic systems in combination with neuroanatomical, electrophysiological, behavioral and pharmacological techniques have begun to elucidate...

Objective: Polycystic ovary syndrome (PCOS) is characterized by biochemical and clinical androgen excess and disturbed ovarian function and is associated with disorders of glucose and lipid metabolism. Isoflavones are phytoestrogens exerting endocrine effects on human hormone and metabolic signaling and may influence symptom penetrance in PCOS. We investigated whether women with PCOS and healthy controls have alterations in their capacity to metabolize hormonally active dietar...

Breakpoint cluster region abelson fusion oncoprotein (BCR-ABL) targeted tyrosine kinase inhibitors (TKIs) are widely used in long-term medications of hematological malignancies. Numerous clinical observations confirmed that these drugs significantly modify the physiology of bone tissue as a side effect. Currently, there are numerous contradictory results regarding the complex effects of TKIs on bone metabolism, as well as there is no clear evidence to explain them, either in t...

Background: Adequate vitamin D supply is necessary for bone metabolism and also for the general maintenance of health. 25OHD is transported primarily bound to vitamin-D binding protein (DBP), but also to albumin. Lower concentration of plasma proteins may cause difficulties in immunoanalytics. Our aim was to investigate the protein dependence of the two most often used 25OHD immuno- (CLIA) and protein binding- (ECLPBA) assays.Methods: levels were measure...

Introduction: Over the past few years the clinical relevance of serum uric acid level has changed. The elevated serum uric acid level not only impairs the joints and the kidney function but it is also linked with an increased risk of cardivascular diseases. The aim of our study was to examine how bones are affected (change of bone mineral density (BMD), bone metabolism parameters, serum 25-hydroxyvitamin D levels and frequency of fractures) by elevated serum uric acid level.</...

Objectives: We previously published the result of CYP24A1 gene expression in one hundred, solely papillary thyroid carcinoma (PTC) compared to its own tumour free control from the same patient. We report an increase in CYP24A1 gene transcription in more than half of analysed PTCs. Elevated CYP24A1 protein expression was also observed in the cancerous tissue section compared to peritumoural normal thyroid tissue. In the present study we aimed to examine CYP24A1 gene transcripti...

Introduction: Lactose intolerance itself is linked with lower peak bone mass (PBM) and with decreased bone mineral density (BMD) which may decrease further with lactose intolerance associated comorbidities. The aim of our study was to examine how bone metabolic parameters are affected (change of bone metabolism markers, BMD and frequency of fractures) in lactose intolerance which was accompanied by previously diagnosed hyperlipidemia or by hypothyroidism.<p class="abstext"...

Introduction: Polycystic ovary syndrome (PCOS), lactase deficiency, nephrolithisasis and thyroid diseases are considered endemic. The aim of our study was to evaluate which of the above-mentioned diseases affect the most the bone metabolic parameters, bone mineral density (BMD) and the prevalence of bone fractures in fertile aged women.Materials and methods: A total of 92 fertile aged women (32.6±5.2 years) were divided into four groups (23 in each)...